Sadly, but all too often, you realize that your relationship was just not meant to be and that you and he will not live happily ever after. It's time for both of you to cut your losses and go your separate ways, preferably on amicable terms.
What, and miss out on all that drama?
Make it clear that whatever your differences, you're not going anywhere. Stick around and constantly criticize him for the things that broke up your relationship, even the things that cannot conceivably be his fault. That's sure to smooth things over.
Of course, the above should not be confused with trying to make the relationship work again. Trying to make the relationship work again, like everything else, is just not your responsibility.